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Your Position: Start > Activin A

Activin A

Brief Information

Name:Activin receptor type-1
Target Synonym:ACTR-I,ACVR1,Activin A Receptor Type 1,Serine/Threonine-Protein Kinase Receptor R1,Activin A Receptor, Type I,ACVRLK2,SKR1,Activin A Receptor, Type II-Like Kinase 2,Hydroxyalkyl-Protein Kinase,Activin Receptor Type-1,EC 2.7.11.30,ACVR1A,ACTRI,EC:2.7.11.30,TSR-I,ALK2,TSRI,FOP,Activin Receptors, Type I,ALK-2,Activin receptor type I,TGF-B superfamily receptor type I,EC 2.7.11,Activin receptor-like kinase 2
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
GMP-ACAH37 Human GMP Human Activin A / INHBA Protein
GMP-ACAH37-structure
ACA-H5314 Human Human Activin A / INHBA Protein, premium grade
ACA-H5314-structure
ACA-H5314-sds
ACA-H421b Human Human Activin A / INHBA Protein, Tag Free
ACA-H421b-structure
ACA-H421b-sds
ACA-H424x Human Human Latent Activin A / INHBA Protein, His Tag
ACA-H424x-structure
ACA-H424x-sds
ACRO Quality

Part of Bioactivity data

ACA-H5314-Cell-based assay
Activin A CELL

Human Activin A Protein, premium grade (Cat. No. ACA-H5314) stimulates Human Activin RIl (Luc) HEK293 Reporter Cell. The specific activity of Human Activin A Protein, premium grade is＞5.00 x 10^2 IU/mg, which is calibrated against WHO Reference Reagent Activin A (Human, Recombinant) NIBSC code: 91/626 (QC tested).

Protocol
ACA-H421b-Cell-based assay
Activin A CELL

Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) inhibits the proliferation of MPC-11 cells. The specific activity of Human Activin A Protein, Tag Free is > 5.00×10^2 IU/mg, which is calibrated against WHO Reference Reagent Activin A (Human, Recombinant) NIBSC code: 91/626 (Routinely tested).

Protocol
ACA-H421b-SPR
Activin A SPR

Human Activin RIIB, His Tag (Cat. No. ACB-H5226) immobilized on CM5 Chip can bind Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) with an affinity constant of 0.216 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
ACA-H424x-SPR
Activin A SPR

Biotinylated Human Activin RIIB Protein, His,Avitag (Cat. No. ACB-H82E3) immobilized on CM5 Chip can bind Human Latent Activin A, His Tag (Cat. No. ACA-H424x) with an affinity constant of 0.147 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

Activin A,INHBA

Background

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various ¦Â subunits (¦ÂA, ¦ÂB, ¦ÂC, and ¦ÂE in mammals), while Inhibins are heterodimers of a unique ¦Á subunit and one of the ¦Â subunits. Activin A is a widely expressed homodimer of two ¦ÂA chains. The ¦ÂA subunit can also heterodimerize with a ¦ÂB or ¦ÂC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human ¦ÂA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat ¦ÂA.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Momelotinib Dihydrochloride CYT-387; GS-0387; GSK-3070785 Approved Ojjaara, Omjjara United States Primary Myelofibrosis; Anemia Glaxosmithkline Llc, Glaxosmithkline Plc 2023-09-15 Polycythemia; Polycythemia Vera; Anemia; Neoplasms; Myeloproliferative Disorders; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Splenomegaly; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BLU-782 BLU-782; IPN-60130 Phase 2 Clinical Blueprint Medicines Corp, Ipsen SA Myositis Ossificans Details
Zilurgisertib INCB-000928; INCB-00928 Phase 2 Clinical Incyte Corp Anemia; Polycythemia Vera; Myelodysplastic Syndromes; Kidney Diseases; Ossification, Heterotopic; Multiple Myeloma; Myositis Ossificans; Primary Myelofibrosis; Thrombocythemia, Essential Details
KER-047 KER-047 Phase 1 Clinical National Center For Advancing Translational Sciences Anemia, Iron-Deficiency; Myositis Ossificans Details
Itacnosertib TP-0184 Phase 1 Clinical Tolero Pharmaceuticals Inc, Sumitomo Dainippon Solid tumours; Anemia Details
BCX-9250 BCX-9250 Phase 1 Clinical Biocryst Pharmaceuticals Inc Myositis Ossificans Details

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